Study of Coagulation Factor VIIa Marzeptacog Alfa (Activated) in Subjects With Inherited Bleeding Disorders
Conditions: Factor VII Deficiency; Glanzmann Thrombasthenia; Hemophilia A With Inhibitor
Intervention: Biological: Coagulation Factor VIIa variant
Sponsor: Catalyst Biosciences
Recruiting
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The Role of Standardized Bleeding Score in Diagnosis of Pediatric Von Willebrand's Disease
Condition: Von Willebrand's Diseased Children, Bleeding Questionnaire is Done
Intervention: Diagnostic Test: Bleeding score ( questionnaire )
Sponsor: Sohag University
Recruiting
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BT200 in Hereditary Bleeding Disorders
Conditions: Von Willebrand Diseases; Hemophilia A
Intervention: Drug: BT200
Sponsor: Medical University of Vienna
Recruiting
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The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Condition: Glanzmann Thrombasthenia
Intervention:
Sponsors: Rockefeller University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
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Evaluation of Hemostasis in Bleeding and Thrombotic Disorders
Conditions: Blood Coagulation Disorders, Inherited; Thrombotic Disorder
Intervention:
Sponsor: The University of Texas Health Science Center, Houston
Recruiting
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A Research Study Investigating Mim8 in People With Haemophilia A
Conditions: Healthy Volunteers; Haemophilia A With or Without Inhibitors
Interventions: Drug: NNC0365-3769 A (Mim8); Drug: Placebo (Mim8)
Sponsor: Novo Nordisk A/S
Recruiting
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AAV Gene Therapy Screening/Observational Protocol (ECLIPSE)
Conditions: Hemophilia B; Blood Coagulation Disorders, Inherited; Blood Coagulation Disorder; Haematologic Disease
Intervention:
Sponsor: Freeline Therapeutics
Recruiting
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Real World Study of Deep Venous Thrombosis. Analysis of Prospective Cases in University Hospitals of São Paulo
Condition: Registry
Intervention: Other: deep venous thrombosis
Sponsors: Fundação Faculdade Regional de Medicina de São José do Rio Preto; University of Ribeirao Preto
Recruiting
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Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
Condition: Hereditary Hemorrhagic Telangiectasia
Intervention:
Sponsors: Unity Health Toronto; National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
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Evaluation of Patients With Immune Function Abnormalities
Conditions: Chronic Granulomatous Disease (CGD); X-Linked Severe Combined Immune Deficiency (XSCID); Leukocyte Adhesion Deficiency 1 (LAD); Graft Versus Host Disease (cGvHD)
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
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Bevacizumab In Hereditary Hemorrhagic Telangiectasia
Condition: Hereditary Hemorrhagic Telangiectasia
Intervention: Drug: Bevacizumab
Sponsor: Hanny Al-Samkari, MD
Recruiting
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BAX 111 rVWF in Pediatrics
Condition: Von Willebrand Disease
Interventions: Biological: von Willebrand factor (Recombinant); Biological: Antihemophilic Factor (Recombinant)
Sponsors: Baxalta now part of Shire; Baxalta Innovations GmbH, now part of Shire
Recruiting
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Investigation of the Genetics of Hematologic Diseases
Conditions: Bone Marrow Failure Syndromes; Erythrocyte Disorder; Leukocyte Disorder; Hemostasis; Blood Coagulation Disorder; Sickle Cell Disease; Dyskeratosis Congenita; Diamond-Blackfan Anemia; Congenital Thrombocytopenia; Severe Congenital Neutropenia; Fanconi Anemia
Intervention:
Sponsors: St. Jude Children's Research Hospital; Boston Children's Hospital; University of Memphis
Recruiting
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World Bleeding Disorders Registry
Conditions: Hemophilia A; Hemophilia B
Intervention:
Sponsor: World Federation of Hemophilia
Recruiting
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TPO-Mimetic Use in Children for Hemotopoietic Failure
Conditions: Bone Marrow Failure Disorders; Aplastic Anemia; Thrombocytopenia; Refractory Cytopenia of Childhood; Myelodysplastic Syndrome(MDS)
Intervention: Drug: Romiplostim
Sponsors: Anjali Sharathkumar; Amgen
Recruiting
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Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients
Conditions: Hereditary Hemorrhagic Telangiectasia; Osler Weber Rendu Disease
Interventions: Drug: Propranolol treatment; Drug: Placebo
Sponsors: University Hospital, Bordeaux; AMRO-HHT-France - Association Maladie de Rendu-Osler
Recruiting
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Registry Study of COAGADEX® Patients With Moderate or Severe Hereditary Factor X Deficiency Undergoing Major Surgery
Condition: Factor 10 Deficiency
Intervention: Drug: Coagadex
Sponsor: Bio Products Laboratory
Recruiting
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Study to Learn More About the Safety of Drug Jivi Over a Long Period of Time in Previously Treated Patients With Hemophilia A (Bleeding Disorder Resulting From a Lack of FVIII) Who Are Receiving Jivi Regularly at Their Treating Doctors to Prevent Bleeding
Condition: Hemophilia A
Intervention: Drug: Damoctocog alfa pegol (Jivi, BAY94-9027)
Sponsor: Bayer
Recruiting
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A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants With Mild or Moderate Hemophilia A Without FVIII Inhibitors
Conditions: Mild Hereditary Factor VIII Deficiency Disease Without Inhibitor; Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor; Hemophilia A
Intervention: Drug: Emicizumab
Sponsor: Hoffmann-La Roche
Recruiting
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Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia
Condition: Hereditary Hemorrhagic Telangiectasia
Intervention: Other: hypoxic induced factors
Sponsor: University Hospital, Essen
Recruiting
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Latin-American Von Willebrand Disease Registry
Condition: Von Willebrand Disease
Intervention: Other: Observation
Sponsor: Academia Nacional de Medicina
Not yet recruiting
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Doxycycline for Hereditary Hemorrhagic Telangiectasia
Condition: Hereditary Hemorrhagic Telangiectasia (HHT)
Interventions: Drug: Doxycycline Hyclate; Drug: Placebo
Sponsors: Unity Health Toronto; Barrow Neurological Institute; Duke University; Feinstein Institute for Medical Research; University of Pittsburgh; Sunnybrook Health Sciences Centre
Recruiting
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Swiss Hemophilia Registry
Condition: Hemophilia and Other Severe Bleeding Disorders
Intervention: Other: Registry
Sponsor: Swiss Hemophilia Network
Recruiting
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Timolol Gel for Epistaxis in Hereditary Hemorrhagic Telangiectasia
Condition: Hereditary Hemorrhagic Telangiectasia
Interventions: Drug: Timolol Gel; Drug: Placebo Gel
Sponsor: Washington University School of Medicine
Recruiting
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Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)
Conditions: Thrombotic Thrombocytopenic Purpura; Congenital Thrombotic Thrombocytopenic Purpura; Familial Thrombotic Thrombocytopenic Purpura; Thrombotic Thrombocytopenic Purpura, Congenital; Upshaw-Schulman Syndrome
Intervention: Other: Observation
Sponsors: University Hospital Inselspital, Berne; Swiss National Science Foundation; Mach Gaensslen Foundation; Baxalta Innovations GmbH, Wien, Austria
Recruiting
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Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)
Conditions: Hereditary Hemorrhagic Telangiectasia; Epistaxis Nosebleed
Intervention: Drug: Tacrolimus capsule (low-dose)
Sponsors: Unity Health Toronto; United States Department of Defense
Recruiting
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Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia
Conditions: Hereditary Hemorrhagic Telangiectasia; Epistaxis
Intervention: Drug: Pazopanib
Sponsors: Cure HHT; University of North Carolina
Not yet recruiting
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Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose
Condition: Telangiectasia, Hereditary Hemorrhagic
Intervention: Drug: bevacuzimab spray
Sponsor: University Hospital, Caen
Recruiting
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Pregnancy and Fibrinogen Disorders
Conditions: Hypofibrinogenemia, Congenital; Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
Intervention:
Sponsors: University Hospital, Geneva; Swiss Hemophilia Network
Recruiting
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Pomalidomide for the Treatment of Bleeding in HHT
Condition: Telangiectasia, Hereditary Hemorrhagic
Interventions: Drug: Pomalidomide Oral Product; Drug: Placebo oral capsule
Sponsors: The Cleveland Clinic; RTI International
Recruiting
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Ultra-low-dose Chest CT for HHT
Condition: Hereditary Hemorrhagic Telangiectasia
Intervention: Diagnostic Test: Ultra-low dose chest CT
Sponsor: Mayo Clinic
Recruiting
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Hereditary Hemorrhagic Telangiectasia (HHT) Research Outcomes Registry
Conditions: Hereditary Hemorrhagic Telangiectasia; HHT; Arteriovenous Malformation of Brain
Intervention: Other: Registry and Saliva sample
Sponsors: Unity Health Toronto; Cure HHT; Dartmouth College
Recruiting
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Evaluation of Video-assisted Instructions of Nasal Self-packing in Patients With HHT
Condition: Hereditary Haemorrhagic Telangiectasia
Intervention: Procedure: video-assisted nasal self-packing
Sponsor: University Hospital, Essen
Recruiting
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Handheld Ultrasound (HHUS) for Home Use in Hemophilia
Conditions: Joint Bleed; Hemophilia A
Intervention: Device: handheld ultrasound: Philips Lumify integrated tele-ultrasound powered by Reacts collaborative platform
Sponsors: Washington Institute for Coagulation; Genentech, Inc.
Recruiting
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Modifiers of Disease Severity in Cerebral Cavernous Malformations
Conditions: Cavernous Angioma, Familial; Cerebral Cavernous Malformations; Cerebral Cavernous Hemangioma
Intervention:
Sponsors: University of California, San Francisco; University of New Mexico; University of Chicago; National Institute of Neurological Disorders and Stroke (NINDS); Boston Children's Hospital; Children's Hospital Medical Center, Cincinnati; Barrow Neurological Institute; Angioma Alliance
Recruiting
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A Gene Transfer Study for Hemophilia A
Condition: Hemophilia A
Intervention: Genetic: SPK-8011
Sponsor: Spark Therapeutics
Recruiting
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ATHN 9: Severe VWD Natural History Study
Condition: Von Willebrand Diseases
Intervention:
Sponsors: American Thrombosis and Hemostasis Network; Takeda
Recruiting
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Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia B
Conditions: Congenital Bleeding Disorder; Haemophilia B
Intervention: Drug: nonacog beta pegol
Sponsor: Novo Nordisk A/S
Recruiting
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Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A
Condition: Hemophilia A
Intervention: Biological: valoctocogene roxaparvovec
Sponsor: BioMarin Pharmaceutical
Recruiting
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Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors
Conditions: Hemophilia A With Inhibitor; Hemophilia A With Anti Factor VIII
Intervention: Biological: Valoctocogene roxaparvovec
Sponsor: BioMarin Pharmaceutical
Recruiting
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Safety and Pharmacokinetics of Subcutaneous Injection of OCTA101 in Adult Patients With Severe Hemophilia A
Condition: Severe Hemophilia A
Intervention: Drug: OCTA101
Sponsor: Octapharma
Recruiting
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Nationwide Awareness Campaign and Call for Dental Screening for HHT in Germany
Conditions: Hereditary Hemorrhagic Telangiectasia; Dental Diseases
Intervention:
Sponsors: University Hospital, Essen; Philipps University Marburg Medical Center; University Hospital, Aachen; German HHT self-help group
Recruiting
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Safety and Efficacy in a ReAl-Life Study in Patients With Haemophilia Treated wIth NovoEight® for Surgery
Condition: Hemophilia
Intervention: Other: no intervention
Sponsor: Nantes University Hospital
Not yet recruiting
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Haemophilia and Bone Loss - PHILEOS Study
Condition: Hemophilia
Interventions: Radiation: Bone densitometry (BMD); Biological: Blood sampling for patients only
Sponsors: Centre Hospitalier Universitaire de Saint Etienne; Ministry of Health, France
Recruiting
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Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial
Conditions: Von Willebrand Diseases; Postpartum Hemorrhage
Interventions: Drug: Recombinant Von Willebrand factor; Drug: Tranexamic Acid Injection [Cyklokapron]
Sponsor: Margaret Ragni
Recruiting
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Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle".
Condition: Hemophilia A
Intervention: Drug: BAY2599023 (DTX201)
Sponsors: Bayer; Ultragenix pharmaceutical
Recruiting
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A Study to Evaluate the Safest Dose Range for FEIBA in Hemophilia A Patients With Inhibitors on Emicizumab
Condition: Hemophilia A With Inhibitor
Intervention: Drug: Feiba
Sponsors: Children's Hospital Los Angeles; Takeda
Recruiting
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Perioperative Eltrombopag in Patients With Inherited Thrombocytopenia
Condition: Thrombocytopenia
Intervention: Drug: Eltrombopag
Sponsors: University Hospital, Toulouse; French network for inherited hemorragic diseases; National Reference Centre for Platelet Pathologies
Recruiting
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Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia A
Condition: Hemophilia A
Intervention: Other: assessment of joint health and bone density
Sponsors: Washington Institute for Coagulation; Genentech, Inc.
Recruiting
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Von Willebrand Disease in the Netherlands
Condition: Von Willebrand Disease
Intervention:
Sponsors: Erasmus Medical Center; Stichting Haemophilia (Dutch Haemophilia Foundation); CSL Behring; Shire
Recruiting
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Longitudinal Studies of Patient With FPDMM
Conditions: Inherited Hematological Diseases; Rare Diseases; FPDMM
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
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Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome
Condition: Hermansky-Pudlak Syndrome (HPS)
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
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UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
Conditions: Adrenoleukodystrophy; Batten Disease; Mucopolysaccharidosis II; Leukodystrophy, Globoid Cell; Leukodystrophy, Metachromatic; Neimann Pick Disease; Pelizaeus-Merzbacher Disease; Sandhoff Disease; Tay-Sachs Disease; Brain Diseases, Metabolic, Inborn; Alpha-Mannosidosis; Sanfilippo Mucopolysaccharidoses
Intervention: Biological: DUOC-01
Sponsors: Joanne Kurtzberg, MD; The Marcus Foundation
Recruiting
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Global Haemostatic Methods Following Administration of Bypassing Agents to Patients With Haemophilia With Inhibitors
Condition: Hemophilia
Intervention:
Sponsor: Karolinska Institutet
Recruiting
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A Study of Factor Inhibitors in Adult Patients With Hemophilia and Von Willebrand's Disease in Upper Egypt
Conditions: Hemophilia; Von Willebrand Diseases; Christmas Disease
Intervention:
Sponsor: Safaa AA Khaled
Not yet recruiting
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A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP)
Condition: Purpura, Thrombotic Thrombocytopenic
Interventions: Biological: BAX930; Biological: Standard of care
Sponsors: Baxalta now part of Shire; Takeda Development Center Americas, Inc.
Recruiting
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A Factor IX Gene Therapy Study (FIX-GT)
Condition: Hemophilia B
Intervention: Biological: FLT180a
Sponsor: University College, London
Recruiting
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Von Willebrand Factor in Pregnancy (VIP) Study
Condition: Von Willebrand Diseases
Interventions: Other: Use of a postpartum diary and additional blood draws; Drug: VWF replacement therapy with Wilate; Drug: Tranexamic acid; Other: Use of a postpartum diary and additional blood draws.
Sponsors: Bloodworks; Mary M. Gooley Hemophilia Center; Ergomed; Octapharma
Recruiting
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A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
Condition: Congenital Thrombotic Thrombocytopenic Purpura
Intervention: Biological: TAK-755
Sponsors: Takeda; Takeda Development Center Americas, Inc.; Shire
Recruiting
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COVID-19 Quarantine on Musculoskeletal Status in Hemophilia
Condition: Hemophilia Arthropathy
Intervention: Other: Observational
Sponsor: Investigación en Hemofilia y Fisioterapia
Recruiting
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Pain and Joint Status With Psychosocial Factors in Patients With Hemophilia
Condition: Hemophilia Arthropathy
Intervention: Other: Observational group
Sponsor: Investigación en Hemofilia y Fisioterapia
Not yet recruiting
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Minimize Menorrhagia in Women With Von Willebrand Disease
Condition: Von Willebrand Diseases
Interventions: Drug: recombinant von Willebrand factor; Drug: tranexamic acid
Sponsors: Margaret Ragni; University of North Carolina; Duke University
Recruiting
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PyROphosPHate Supplementation to Fight ECtopIc Calcification in PseudoXanthoma Elasticum
Condition: Pseudoxanthoma Elasticum
Interventions: Drug: study treatment PPI; Drug: Study comparator ETI
Sponsor: Centre Hospitalier Universitaire de Nice
Not yet recruiting
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Analysis of Specimens From Individuals With Pulmonary Fibrosis
Conditions: Pulmonary Fibrosis; Healthy Volunteers; Hermansky-Pudlak Syndrome (HPS)
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
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At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
Conditions: All Diagnosed Health Conditions; ADD/ADHD; Alopecia Areata; Ankylosing Spondylitis; Asthma; Atopic Dermatitis Eczema; Beta Thalassemia; Bipolar Disorder; Breast Cancer; Celiac Disease; Cervical Cancer; Chronic Inflammatory Demyelinating Polyneuropathy; Chronic Kidney Diseases; Chronic Obstructive Pulmonary Disease; Colon Cancer; Colorectal Cancer; Crohn's Disease; Cystic Fibrosis; Depression; Diabetes Mellitus; Duchenne Muscular Dystrophy; Endometriosis; Epilepsy; Facioscapulohumeral Muscular Dystrophy; G6PD Deficiency; General Anxiety Disorder; Hepatitis B; Hereditary Hemorrhagic Telangiectasia; HIV/AIDS; Human Papilloma Virus; Huntington's Disease; Idiopathic Thrombocytopenic Purpura; Insomnia; Kidney Cancer; Leukemia; Lung Cancer; Lupus Nephritis; Lymphoma; Melanoma; Multiple Myeloma; Multiple Sclerosis; Myositis; Myotonic Dystrophy; Ovarian Cancer; Pancreatic Cancer; Parkinson's Disease; Polycystic Kidney Diseases; Prostate Cancer; Psoriasis; Psoriatic Arthritis; Rosacea; Scleroderma; Sickle Cell Anemia; Sickle Cell Trait; Sjogren's Syndrome; Skin Cancer; Spinal Muscular Atrophy; Systemic Lupus Erythematosus; Thrombotic Thrombocytopenic Purpura; Trisomy 21; Ulcerative Colitis
Intervention:
Sponsor: Sanguine Biosciences
Recruiting
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Study of Chediak-Higashi Syndrome
Condition: Chediak Higashi Syndrome
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
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A Non-interventional Cohort Safety Study of Patients With hATTR-PN
Condition: Hereditary Transthyretin Amyloidosis With Polyneuropthy
Intervention: Other: Data Collection
Sponsors: Akcea Therapeutics; United BioSource, LLC
Not yet recruiting
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Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases
Conditions: Von Willebrand Diseases; Glanzmann Thrombasthenia
Interventions: Device: Sublingual videomicroscopy; Biological: blood sample
Sponsor: University Hospital, Lille
Not yet recruiting
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An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B
Condition: Hemophilia B
Intervention: Drug: Alprolix
Sponsor: Swedish Orphan Biovitrum
Recruiting
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Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active Conditions
Condition: Hemophilia A
Intervention: Other: Observation of the association between clotting factor level and risk of bleeding whilst physical activity
Sponsors: Prof. Dr. Dr. Thomas Hilberg; Takeda; University of Bonn
Recruiting
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Assessing Physician and Hemophilia A Patient Reasons and Expectations for Switching Treatment to Kovaltry & Jivi: A Nested Study Within an Existing Registry
Condition: Hemophilia A
Intervention: Drug: New FVIII products
Sponsors: Bayer; American Thrombosis and Hemostasis Network
Recruiting
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A Study of the Burden of Illness and Treatment Patterns in Teenagers and Adults With Hereditary Angioedema
Condition: Hereditary Angioedema
Intervention:
Sponsor: Takeda
Not yet recruiting
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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Conditions: Hematologic Malignancies; Inherited Disorders of Metabolism; Inherited Abnormalities of Platelets; Histiocytic Disorders; Acute Myelogenous Leukemia (AML or ANLL); Acute Lymphoblastic Leukemia (ALL); Other Acute Leukemia; Chronic Myelogenous Leukemia (CML); Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases; Other Leukemia; Hodgkin Lymphoma; Non-hodgkin Lymphoma; Multiple Myeloma/ Plasma Cell Disorder (PCD); Inherited Abnormalities of Erythrocyte Differentiation or Function; Disorders of the Immune System; Autoimmune Diseases; Severe Aplastic Anemia
Intervention: Drug: A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Sponsors: Center for International Blood and Marrow Transplant Research; National Marrow Donor Program
Recruiting
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Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
Condition: Hemophilia A
Intervention: Drug: Damoctocog alfa pegol (Jivi, Bay94-9027)
Sponsor: Bayer
Recruiting
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ATHN 7: Hemophilia Natural History Study
Conditions: Hemophilia A With Inhibitor; Haemophilia A Without Inhibitor; Hemophilia B With Inhibitor; Haemophilia B Without Inhibitor
Intervention:
Sponsors: American Thrombosis and Hemostasis Network; Genentech, Inc.
Recruiting
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China Registry for Genetic / Metabolic Liver Diseases
Condition: Genetic/Metabolic Liver Diseases
Intervention: Drug: Standard of care
Sponsors: Beijing Friendship Hospital; Beijing YouAn Hospital; Henan Provincial People's Hospital; Beijing Ditan Hospital; Hebei Medical University Third Hospital; Peking University First Hospital; Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital; Nanfang Hospital of Southern Medical University; Logistics University of Chinese People's Armed Police Forces; Beijing Anzhen Hospital; West China Second University Hospital of Sichuan University; Jinshan Hospital Fudan University; Fudan University
Recruiting
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Accessibility of Prophylaxis and On-demand Treatment for Persons With Haemophilia and Other Coagulation Deficiencies
Conditions: Health Services Accessibility; Blood Coagulation Factor Deficiencies
Intervention:
Sponsors: RESCUe - RESeau Cardiologie Urgence / RESUVal - RESeau des Urgences de la vallée du Rhône; Hospices Civils de Lyon
Recruiting
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Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Patients With Severe Hemophilia A or B
Conditions: Hemophilia A; Hemophilia B
Intervention: Drug: PF-06741086
Sponsor: Pfizer
Recruiting
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Frequency of Hemorrhages Associated With the Functional Anomalies of Willebrand Factor in Emergency Patients
Condition: Von Willebrand Diseases
Intervention:
Sponsor: University Hospital, Lille
Recruiting
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ATHN 8: PUPs Matter Study
Conditions: Hemophilia; Hemophilia A; Hemophilia B; Hemophilia A With Inhibitor; Hemophilia B With Inhibitor; Haemophilia B Without Inhibitor; Haemophilia A Without Inhibitor; Haemophilia
Intervention:
Sponsors: American Thrombosis and Hemostasis Network; CSL Behring; Octapharma; Takeda
Recruiting
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Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease VWD) Patients <6 Years of Age
Condition: Von Willebrand Disease
Intervention: Drug: wilate
Sponsor: Octapharma
Not yet recruiting
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Registry of Patients With Von WilLEbrand Disease Treated With Voncento®
Condition: Von Willebrand Disease
Intervention: Biological: Voncento®
Sponsor: CSL Behring
Recruiting
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rVWF Pediatric and Adult Study
Condition: Von Willebrand Disease
Interventions: Biological: rVWF; Biological: rFVIII
Sponsors: Baxalta now part of Shire; Baxalta Innovations GmbH, now part of Shire
Recruiting
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Effectiveness and Tolerability of Eqwilate in Real-life Conditions
Condition: VWD - Von Willebrand's Disease
Intervention: Biological: Eqwilate
Sponsor: Octapharma
Recruiting
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Treatment of Hemophilia A Patients With FVIII Inhibitors
Condition: Hemophilia A
Interventions: Biological: Nuwiq; Biological: Octanate; Biological: Wilate; Biological: Emicizumab; Biological: Recombinant factor VIIa (rFVIIa); Biological: Activated prothrombin complex concentrate (aPCC)
Sponsors: Emory University; Octapharma
Recruiting
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Evaluation of Immune Status Before and After Splenectomy in Immune Thrombocytopenia Patients
Conditions: Thrombocytopenia; Splenectomy
Intervention: Procedure: splenectomy
Sponsor: Zhang Lei
Recruiting
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Evaluation of Bleeding Score in Egyptian Patients With vWD Type I and Correlate it With Laboratory Parameters
Condition: Von Willebrand Disease, Type 1
Intervention: Diagnostic Test: The von Willebrand Antigen level
Sponsor: Assiut University
Not yet recruiting
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Differences in Preparation for Small Bowel Capsule Endoscopy
Conditions: Capsule Endoscopy; Inflammatory Bowel Diseases; Celiac Disease
Interventions: Drug: Klean Prep; Other: Clear liquids only
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Hotel Dieu Hospital
Recruiting
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Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia A Patients.
Condition: Hemophilia A
Intervention: Drug: Recombinant Human Coagulation FVIII
Sponsor: Sinocelltech Ltd.
Recruiting
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ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)
Condition: Hemophilia A
Interventions: Biological: ADVATE; Biological: ADYNOVI
Sponsors: Baxalta now part of Shire; Baxalta Innovations GmbH, now part of Shire
Recruiting
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Von Willebrand Antigen and Activity as Novel Biomarkers of Hemostasis in Inflammatory Bowel Disease
Conditions: Inflammatory Bowel Diseases; Von Willebrand Diseases
Intervention: Diagnostic Test: von willebrand antigen and activity
Sponsor: Assiut University
Recruiting
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Gene Therapy for Chinese Hemophilia A
Conditions: Hemophilia A; Gene Therapy
Intervention: Genetic: Injection of GS001
Sponsor: Institute of Hematology & Blood Diseases Hospital
Recruiting
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The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B
Condition: Hemophilia
Interventions: Other: Blood sample; Other: Questionnaire; Other: MRI-imaging; Other: Physical examination
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting
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Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A
Condition: Hemophilia A
Intervention: Drug: Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection
Sponsors: Zhengzhou Gensciences Inc; Jiangsu Gensciences lnc.
Recruiting
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Study of TAK-672 in Participants With Acquired Hemophilia A
Condition: Acquired Hemophilia A
Intervention: Biological: TAK-672
Sponsor: Takeda
Not yet recruiting
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Development of a Device for Evaluating Primary Hemostasis Under Whole Blood Flow Conditions
Conditions: Von Willebrand Diseases; Major Constitutional Thrombopathy; Patient on Antiplatelet Drugs
Intervention: Biological: Blood sampling
Sponsor: Centre Hospitalier Universitaire Dijon
Recruiting
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Rofecoxib Efficacy and Safety Evaluation Trial in Hemophilic Arthropathy
Condition: Hemophilic Arthropathy
Interventions: Drug: TRM-201 (Rofecoxib); Drug: Placebo
Sponsor: Tremeau Pharmceuticals, Inc.
Recruiting
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Trial of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab
Condition: Acquired Hemophilia A
Interventions: Drug: Steroid; Drug: Rituximab; Drug: Cyclophosphamide
Sponsors: Zhang Lei; Qilu Hospital of Shandong University; Tianjin First Central Hospital; The Second Affiliated Hospital of Kunming Medical University; Henan Cancer Hospital
Recruiting
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A Safety Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor
Condition: Hemophilia
Intervention: Drug: STSP-0601 for Injection
Sponsor: Staidson (Beijing) Biopharmaceuticals Co., Ltd
Recruiting
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Impact of Von Willebrand Factor and Its Multimers on Angiogenesis
Condition: Von Willebrand Diseases
Intervention: Other: no intervention
Sponsor: Nantes University Hospital
Not yet recruiting
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A Study of TAK-660 in Surgical Procedures for People With Hemophilia A.
Condition: Hemophilia A
Intervention: Biological: PEGylated Recombinant Factor VIII
Sponsor: Takeda
Not yet recruiting
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Antithrombin III in Infectious Disease Caused by COVID-19
Conditions: Antithrombin III Deficiency; Covid19
Intervention: Drug: Antithrombin III
Sponsors: Enrique Ginzburg; Grifols Biologicals, LLC
Recruiting
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A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health
Condition: Hemophilia A
Intervention: Drug: ELOCTA
Sponsor: Swedish Orphan Biovitrum
Recruiting
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Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults
Condition: Hemophilia A
Intervention: Biological: PF-07055480 (giroctocogene fitelparovec): Recombinant AAV2/6 Human Factor VIII Gene Therapy
Sponsor: Pfizer
Recruiting
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Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants
Condition: Hemophilia A
Intervention: Drug: Emicizumab
Sponsor: Hoffmann-La Roche
Recruiting
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iT-based Sports Therapy Application in Haemophilia
Conditions: Haemophilia; Sports Physical Therapy
Intervention: Device: Trainings application
Sponsors: Prof. Dr. Dr. Thomas Hilberg; Pfizer
Recruiting
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PHYSICAL ACTIVITY AND FVIII CLEARANCE: RELEVANCE FOR PERSONALIZED THERAPY IN SEVERE HAEMOPHILIA A (PHYSEMO)
Condition: Hemophilia A
Intervention: Device: SenseWear® armband device
Sponsor: Catholic University of the Sacred Heart
Recruiting
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